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Synthetic Nucleic Acids as Inhibitors of Gene Expression

In the post-genomic era we have, at our fingertips, an incredible array of genomic sequences from a multitude of complex organisms. There remains, however, the critical need to understand the precise roles individual genes play in complex biological milieu. Synthetic nucleic acids are at the cutting-edge of molecular strategies that target genes of interest in a specific, efficient and cost-effective manner. These tools are now being...

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Handbook of Nature-Inspired and Innovative Computing

As computing devices proliferate, demand increases for an understanding of emerging computing paradigms and models based on natural phenomena. Neural networks, evolution-based models, quantum computing, and DNA-based computing and simulations are all a necessary part of modern computing analysis and systems development. Vast literature exists on these new paradigms and their implications for a wide array of applications. This compreh...

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Oxford Handbook of Nucleic Acid Structure

The Oxford Handbook of Nucleic Acid Structure is a comprehensive reference on all aspects of nucleic acid structure, with particular emphasis on the results from X-ray crystallography and NMR studies. In nineteen chapters by leading experts, it describes in detail the variety of DNA and RNA structural types discovered to date, progressing systematically through the polymorphs of double helical DNA through to the higher-order organiza...

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The Neuropsychopathology of Schizophrenia

One of the first major theoretical reviews of schizophrenia since the publication of the 5th edition of the APA’s Diagnostic and Statistical Manual, the DSM-5, this volume is a landmark in the history of schizophrenia research. It assembles recent groundbreaking developments in research on schizophrenia and reaffirms its central place in the mental health research agenda. Significantly, this volume reflects the paradigmatic shift in ...

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Plant Cold Hardiness: From the Laboratory to the Field (Cabi)

Presenting the latest research on the effects of cold and sub-zero temperatures on plant distribution, growth and yield, this comprehensive volume contains 28 chapters by international experts covering basic molecular science to broad ecological studies on the impact of global warming, and an industry perspective on transgenic approaches to abiotic stress tolerance. With a focus on integrating molecular studies in the laboratory with...

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Molecular Mechanisms of Cell Differentiation in Gonad Development

This book presents the current state of knowledge on the origin and differentiation of cell lines involved in the development of the vertebrate male and female gonads with particular emphasis on the mouse. It also discusses the processes leading to the testis- and ovary-specific structures and functions. The individual chapters review the origin and differentiation of the somatic cells of the genital ridges; the formation and migrati...

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Chromosome Architecture: Methods and Protocols

This volume details a valuable collection of protocols and reviews, such as emerging experimental and theoretical approaches. These approaches have resulted in a substantial improvement in the understanding of chromosome architecture.Chromosome Architecture: Methods and Protocols guides readers through cutting-edge interdisciplinary methods which allow for an understanding of architecture of chromosomes with exceptionally enhanced re...

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DNA Promise and Peril

The genetic revolution has provided incredibly valuable information about our DNA, information that can be used to benefit and inform—but also to judge, discriminate, and abuse. An essential reference for living in today's world, this book gives the background information critical to understanding how genetics is now affecting our everyday lives. Written in clear, lively language, it gives a comprehensive view of exciting recent disc...

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The American Woodland Garden: Capturing the Spirit of the Deciduous Forest

North America's eastern half, roughly from the Midwest to the Atlantic, was once a great deciduous forest. Although centuries of human intervention have cleared much of the land, the timeless forest remains in the spirit of the place. Today, even the shortest period of human neglect allows for the resurgence of the process of forest creation. The greatest gardens — and happiest gardeners — in this area will be those that take into ac...

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Systems Biology: Properties of Reconstructed Networks

Genome sequences are now available that enable us to determine the biological components that make up a cell or an organism. The new discipline of systems biology examines how these components interact and form networks, and how the networks generate whole cell functions corresponding to observable phenotypes. This textbook describes how to model networks, determine their properties, and relate these to phenotypic functions. Some kno...